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Hi all Thank you for all the work down with valetudo This issue shall gather information on persistent maps how they behave etc 

Valetudo Persistant Maps, No-Go Zones and Virtual Barriers

maybe to come back at the topic of problem solving:
did you check if the contents of rc.local are actually used?
you can do this with the command
iptables-save
The output should look like following:
root@rockrobo:~# iptables-save
# Generated by iptables-save v1.4.21 on Wed Jan 15 18:07:02 2020
*raw
:PREROUTING ACCEPT [146139:34509973]
:OUTPUT ACCEPT [156691:78271808]
COMMIT
# Completed on Wed Jan 15 18:07:02 2020
# Generated by iptables-save v1.4.21 on Wed Jan 15 18:07:02 2020
*nat
:PREROUTING ACCEPT [3959:280612]
:INPUT ACCEPT [550:47854]
:OUTPUT ACCEPT [2395:145697]
:POSTROUTING ACCEPT [2397:145817]
-A OUTPUT -d 203.0.113.1/32 -p tcp -m tcp --dport 80 -j DNAT --to-destination 127.0.0.1:8053
-A OUTPUT -d 203.0.113.1/32 -p udp -m udp --dport 8053 -j DNAT --to-destination 127.0.0.1:8053
COMMIT
# Completed on Wed Jan 15 18:07:02 2020
# Generated by iptables-save v1.4.21 on Wed Jan 15 18:07:02 2020
*mangle
:PREROUTING ACCEPT [146139:34509973]
:INPUT ACCEPT [142726:34275903]
:FORWARD ACCEPT [0:0]
:OUTPUT ACCEPT [156697:78272632]
:POSTROUTING ACCEPT [156852:78286977]
COMMIT
# Completed on Wed Jan 15 18:07:02 2020
# Generated by iptables-save v1.4.21 on Wed Jan 15 18:07:02 2020
*filter
:INPUT ACCEPT [142727:34275943]
:FORWARD ACCEPT [0:0]
:OUTPUT ACCEPT [156699:78273700]
-A INPUT -p udp -m udp --dport 6665 -j DROP
-A INPUT -p tcp -m tcp --dport 6665 -j DROP
-A OUTPUT -d 203.0.113.1/32 -j REJECT --reject-with icmp-port-unreachable
COMMIT
# Completed on Wed Jan 15 18:07:02 2020
Check also the same for ipv6:
root@rockrobo:~# ip6tables-save# Generated by ip6tables-save v1.4.21 on Wed Jan 15 18:07:48 2020*raw :PREROUTING ACCEPT [1445:267510] :OUTPUT ACCEPT [16:2851] COMMIT# Completed on Wed Jan 15 18:07:48 2020 # Generated by ip6tables-save v1.4.21 on Wed Jan 15 18:07:48 2020*mangle :PREROUTING ACCEPT [1445:267510] :INPUT ACCEPT [0:0] :FORWARD ACCEPT [0:0] :OUTPUT ACCEPT [16:2851] :POSTROUTING ACCEPT [0:0] COMMIT# Completed on Wed Jan 15 18:07:48 2020 # Generated by ip6tables-save v1.4.21 on Wed Jan 15 18:07:48 2020*filter :INPUT DROP [0:0] :FORWARD DROP [0:0] :OUTPUT DROP [16:2851] -A OUTPUT -d 2001:db8::1/128 -j REJECT --reject-with icmp6-port-unreachable COMMIT# Completed on Wed Jan 15 18:07:48 2020`